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Allegra - fexofenadine - is an oral, "second generation" antihistamine that is used to treat the signs and symptoms of allergy that are due to histamine. It is similar to the other second generation antihistamines loratadine (Claritin), cetirizine (Zyrtec) and azelastine (Astelin). Histamine is a chemical that is responsible for many of the signs and symptoms of allergic reactions, for example, swelling of the lining of the nose, sneezing, and itchy eyes. Histamine is released from histamine-storing cells (mast cells) and then attaches to other cells that have receptors for histamine. The attachment of the histamine to the receptors causes the cell to be "activated," releasing other chemicals that produce the effects that we associate with allergy, e.g., sneezing. Fexofenadine blocks one type of receptor for histamine (the H1 receptor) and thus prevents activation of H1 receptor-containing cells by histamine. Unlike the first generation antihistamines, fexofenadine and other second-generation antihistamines do not readily enter the brain from the blood, and, therefore, they cause less drowsiness. Fexofenadine was approved by the FDA in July, 1995.

Allegra-D is a combination of an antihistamine (fexofenadine) and a decongestant (pseudoephedrine). Fexofenadine is a long- acting antihistamine that blocks the actions of histamine which are responsible for some of the symptoms of allergic reactions. It is one of a few antihistamines that does not cause sedation. Pseudoephedrine decongests by causing blood vessels to narrow thereby preventing fluid from leaving the vessels and causing the tissues to swell.

Seasonal Allergic Rhinitis - fexofenadine, is indicated for the relief of symptoms associated with seasonal allergic rhinitis in adults and children 6 years of age and older. Symptoms treated effectively with this medicine were sneezing, rhinorrhea, itchy nose / palate / throat, itchy /watery/ red eyes.

Chronic Idiopathic Urticaria - fexofenadine also is indicated for treatment of uncomplicated skin manifestations of chronic idiopathic urticaria. It significantly reduces pruritus and the number of wheals.

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