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Altace, or generic Altace, ramipril, is used to lower hypertension (high blood pressure) and to treat heart failure. This medicament decreases certain chemicals that tighten the blood vessels, so blood flows more smoothly and the heart can pump more efficiently. Ramipril, is indicated to reduce the risk of stroke, heart attack, or death from cardiovascular (CV) causes in patients 55 or older who are at high risk for these events either because of a history of CV disease or because of diabetes plus at least one other CV risk factor.
Ramipril, controls high blood pressure and heart failure but does not cure them. Continue to take ramipril even if you feel well. Do not stop taking this medicine without talking to your doctor.

Ramipril belongs in a class of drugs called angiotensin converting enzyme (ACE) inhibitors which are used for treating high blood pressure and heart failure and for preventing kidney failure due to high blood pressure and diabetes. Other ACE inhibitors are enalapril (Vasotec), quinapril (Accupril), captopril (Capoten), fosinopril (Monopril), benazepril (Lotensin), lisinopril (Zestril, Prinivil), moexipril (Univasc) and trandolapril (Mavik). ACE is important because it produces the protein, angiotensin II. Angiotensin II contracts the muscles of most arteries in the body, including the heart, thereby narrowing the arteries and elevating the blood pressure. In the kidney, the narrowing caused by angiotensin II also increases blood pressure and decreases the flow of blood. ACE inhibitors such as ramipril lower blood pressure by reducing the production of angiotensin II, thereby relaxing the arterial muscles and enlarging the arteries. The enlargement of the arteries throughout the body reduces the blood pressure against which the heart must pump blood, and it becomes easier for the heart to pump blood. The arteries supplying the heart with blood also enlarge. This increases the flow of blood and oxygen to the heart, and this improves further the ability of the heart to pump blood. The effects of ACE inhibitors are particularly beneficial to people with congestive heart failure. In the kidneys, the enlargement of the arteries also reduces blood pressure and increases blood flow. The FDA approved ramipril in 1991.

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