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AVANDIA

Avandia - Rosiglitazone maleate, is an oral antidiabetic agent for treatment of type 2 diabetes.
Rosiglitazone is a drug that reduces the amount of glucose (sugar) in the blood. It is in a class of anti-diabetic drugs called "thiazolidinediones" (TZD) that are used in the treatment of type II diabetes. The other member in this class is pioglitazone (Actos). (Another member of this class, troglitazone or Rezulin, was removed from the market because of liver toxicity.) Patients with type II diabetes cannot make enough insulin, and the cells of their body do not respond normally to the reduced amounts of insulin that are present. (Insulin is the hormone produced by the pancreas that stimulates cells to remove glucose from the blood.) Rosiglitazone often is referred to as an "insulin sensitizer" because it attaches to the insulin receptors on cells throughout the body and causes the cells to become more sensitive (more responsive) to insulin. As a result, more glucose is removed from the blood. At least some insulin must be produced by the pancreas in order for rosiglitazone to function. Rosiglitazone was approved by the FDA on May 28, 1999.

SIDE EFFECTS - The following side effects have been reported: Upper respiratory tract infection, Injury, Headache, Back pain, Hyperglycemia, Fatigue, Sinusitis, Diarrhea and Hypoglycemia.
There were a small number of patients treated with Rosiglitazone who had adverse events of anemia and edema. Overall, these events were generally mild to moderate in severity and usually did not require discontinuation of treatment with the drug.