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Bextra. Valdecoxib is an oral drug that belongs to the family of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). NSAIDs are used primarily to treat pain and arthritis. Other NSAIDs include aspirin and aspirin-related drugs, ibuprofen (Motrin), indomethacin (indocin), naproxen (Naprosyn), diclofenac (Voltaren), sulindac (Clinoril), ketoprofen (Orudis), etc. Valdecoxib works by altering the production of prostaglandins, chemicals manufactured by the body that promote the inflammation of arthritis and cause the pain, swelling and tenderness of arthritic joints. Valdecoxib, like the newer NSAIDs celecoxib (Celebrex) and rofecoxib (Vioxx), blocks one of the enzymes that makes prostaglandins (cyclooxygenase 2), resulting in lower concentrations of prostaglandins. As a consequence, pain, swelling and tenderness of joints due to arthritis are reduced. Valdecoxib (like celecoxib and rofecoxib) differs from most other NSAIDs in that it causes less inflammation and ulceration of the stomach and intestine (at least with short-term treatment) and does not interfere with the clotting of blood.

SIDE EFFECTS: The most common side effects of valdecoxib are headache, abdominal pain, diarrhea, nausea, flatulence and insomnia. Other side effects include fainting, kidney failure, heart failure, fluid retention, aggravation of hypertension, chest pain, ringing in the ears, deafness, stomach and intestinal ulcers, bleeding, blurred vision, anxiety, photosensitivity, weight gain, water retention, flu-like symptoms, drowsiness and weakness. Serious allergic reactions have been reported with valdecoxib; it is recommended that patients who experience a rash after beginning therapy with valdecoxib should discontinue valdecoxib immediately and seek the advise of their physician. Although valdecoxib is not a sulfonamide itself (unlike celecoxib), it is recommended that patients with an allergy to sulfonamides ("sulfas") should not take valdecoxib. Although the chances of stomach or intestinal ulceration or bleeding with valdecoxib are low, a small risk of these side effects remains.

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