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GENERIC PAXIL: paroxetine (pa-ROX-e-teen)


Paroxetine - generic Paxil - is used to treat depression, panic, attacks, obsessive compulsive disorder (OCD), social anxiety disorder (social phobia) and generalized anxiety disorders (GAD). This medication may also be used to treat severe premenstrual syndrome (PMDD), sexual problems in men (premature ejaculation), nerve problems associated with diabetes, chronic headaches, or post-traumatic stress disorder (PTSD). Paxil is an anti-depressant drug that affects the chemicals that nerves in the brain use to communicate with one another. These chemical messengers, called neurotransmitters, are released by one nerve and taken up by other nerves. Neurotransmitters that are released but not taken up by other nerves are taken up by the nerves that release them ("reuptake"). Many experts believe that it is an imbalance among the amounts of the different neurotransmitters that are released that causes depression. Paxil works by inhibiting the reuptake of serotonin by the nerves that release it, an action which allows more serotonin to be available to be taken up by other nerves. Paroxetine is in a class of drugs called selective serotonin reuptake inhibitors (SSRIs), a class that also contains fluoxetine (Prozac) and sertraline (Zoloft).

SIDE EFFECTS: The most commonly noted side effects associated with paroxetine are anxiety, sweating, nausea, decreased appetite, somnolence (sleepiness), dizziness, insomnia, and male sexual disturbances. Dry mouth occurs in about 18% of patients taking paroxetine.

The withdrawal of treatment with many anti-depressants has been associated with troublesome symptoms. Symptoms have been particularly frequent with anti-depressants, like paroxetine, classified as SSRI's. Specifically, the incidence of symptoms upon withdrawal is between 17% and 30% with paroxetine and fluvoxamine (Luvox), but less than 5% with other SSRI's. The most common symptoms of withdrawal have been dizziness, tiredness, tingling of the extremities, nausea, vivid dreams, irritability, and poor mood. Other symptoms have included visual disturbances and headaches.

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