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Felodipine - generic Plendil - is used to lower hypertension (high blood pressure). Felodipine is effective alone or in combination with other high blood pressure medications. A type of medication called a calcium channel blocker. Other calcium channel blockers in the DHP class include nifedipine (Procardia, Adalat), amlodipine (Norvasc), nisoldipine (Sular), nicardipine (Cardene), and isradipine (Dynacirc). Calcium is necessary for muscle cells to contract. Felodipine prevents calcium from being released within the muscle cells of the small arteries and thereby causes the muscles to relax and the arteries to dilate or expand. Felodipine has little or no effect on the muscles of veins or the heart. Felodipine, eases the workload of the heart by slowing down its muscle contractions and the passage of nerve impulses through it. This improves blood flow through the heart and throughout the body, reduces blood pressure, and helps prevent angina pain (chest pain, often accompanied by a feeling of choking, usually caused by lack of oxygen in the heart due to clogged arteries). Felodipine was approved by the FDA in 1991.

Amlodipine, bepridil, diltiazem, felodipine, flunarizine, isradipine, nicardipine, nifedipine, nimodipine, and verapamil belong to the group of medicines called calcium channel blocking agents.

SIDE EFFECTS: Peripheral edema (swollen ankles and feet) and headache are the most common side effects of Plendil. Dizziness also may occur.

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