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Sertraline HCl is used to treat depression, panic disorder, obsessive-compulsive disorders (OCD), post-traumatic stress disorder (PTSD), and a severe form of premenstrual syndrome (premenstrual dysphoric disorder - PMDD). Sertraline works by helping to restore the balance of certain natural chemicals in the brain. 

Sertraline belongs to a class of drugs called selective serotonin reuptake inhibitors (SSRI). Other drugs in this class are Prozac (fluoxetine), Paxil (paroxetine), Celexa (citalopram) and Luvox (fluvoxamine). Serotonin is a neurotransmitter (a chemical messenger) produced by nerve cells in the brain that is used by the nerves to communicate with one another. Sertraline inhibits the reuptake of serotonin from the area between nerves (synapses). The leading theory is that drugs such as sertraline restore the chemical balance among neurotransmitters in the brain. Sertraline was approved by the Food and Drug Administration in December, 1991.

SIDE EFFECTS: The most common side effects of sertraline are sleepiness, nervousness, insomnia, dizziness, nausea, tremor, skin rash, upset stomach, loss of appetite, headache, diarrhea, abnormal ejaculation, dry mouth and weight loss. Important side effects are irregular heartbeats, allergic reactions and activation of mania in patients with bipolar disorder.

If sertraline is discontinued abruptly, some patients experience symptoms such as abdominal cramps, flu like symptoms, fatigue and memory impairment. Although this reaction is not well established, it is reasonable to gradually reduce the dose when therapy is discontinued.

It has been suggested that SSRIs may cause depression to worsen and even lead to suicide in a small number of patients. These potential side effects are difficult to evaluate in depressed patients because depression can progress with or without treatment, and suicide is itself a consequence of depression. Moreover, the evidence supporting these potential side effects is weak.

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